![]() ![]() The "alternatives," such as they were, fell into roughly three buckets: Fit into my clients' development budgetsĪnd by alternatives, I mean a rapid application development environment for desktop, line of business applications.Had strong print-ready reporting capabilities.I wanted a desktop application framework that was: Many times during my first ten years working at Grandjean & Braverman, I got fed up with Access and went looking for alternatives. To answer this, I need to go back to my early years as a programmer again. If not Access, what should we be using instead? There's an obvious two-word followup to Daniel's question about Access as a development environment: Take the rest of my opinions with the appropriate grains of salt. For better or worse, I will be supporting Access applications for many more years. I no longer have the luxury of being indifferent to Access. Over those ten years, those dozen or so applications had expanded to about three dozen Access programs. I did not care what programming language I would be using at my new job I was just happy to be programming! Over time, though, I came to love and appreciate Access's capabilities.įast forward ten years and I had become the proud new owner of Grandjean & Braverman, Inc. As luck would have it, though, I landed a software job working for someone who had spent the past ten years developing more than a dozen Access applications. I resigned myself to the fact that I would not be able to write software for a living. When I left the Army in 2007, my wife and I moved back to my small hometown in northeast Pennsylvania. I have been developing and maintaining Access applications my entire professional programming career. That's a difficult question for me to answer. ![]() This line in particular has been haunting me, "from a moral and ethical standpoint, as a developer, are you truly looking out for your users’ best interests, or simply your own, by continuing to promote and use Microsoft Access?" ( emphasis added) I've been thinking about Daniel's post for the past 24 hours. ![]()
0 Comments
![]() In parallel with repression by Keap1, Nrf2 is also repressed by β-transducin repeat-containing protein (β-TrCP), present in the Skp1–cullin-1–F-box protein (SCF) ubiquitin ligase complex SCF β-TrCP. The ability of Keap1 to repress Nrf2 can be attenuated by p62/sequestosome-1 in a mechanistic target of rapamycin complex 1 (mTORC1)-depen-dent manner, thereby allowing refeeding after fasting to increase Nrf2-target gene expression. Thus modification of Cys residues in Keap1 blocks CRL Keap1 activity, allowing newly translated Nrf2 to accumulate rapidly and induce its target genes. Its ability to orchestrate adaptation to oxidants and electrophiles is due principally to stress-stimulated modification of thiols within one of its repressors, the Kelch-like ECH-associated protein 1 (Keap1), which is present in the cullin-3 RING ubiquitin ligase (CRL) complex CRL Keap1. Nrf2 is subject to regulation at multiple levels. In addition to cytoprotection, Nrf2 also controls genes involved in intermediary metabolism, positively regulating those involved in NADPH generation, purine biosynthesis, and the β-oxidation of fatty acids, while suppressing those involved in lipogenesis and gluconeogenesis. Activation of Nrf2 can, however, serve as a double-edged sword because some of the genes it induces may contribute to chemical carcinogenesis by promoting futile redox cycling of polycyclic aromatic hydrocarbon metabolites or confer resistance to chemotherapeutic drugs by increasing the expression of efflux pumps, suggesting its cytoprotective effects will vary in a context-specific fashion. It therefore plays a pivotal role in both intrinsic resistance and cellular adaptation to reactive oxygen species (ROS) and xenobiotics. ![]() ![]() Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-inducible expression of a battery of genes encoding key components of the glutathione-based and thioredoxin-based anti-oxidant systems, as well as aldo-keto reductase, glutathione S-transferase, and NAD(P)H:quinone oxi-doreductase-1 drug-metabolizing isoenzymes along with multidrug-resistance-associated efflux pumps. ![]() ![]() ![]() I kinda wish these programs had (do any of them have it?) a text-only way of connecting pins for schematics, so there's no mistake as to what connects where. It started well,m I defined my own components there that I need, but as soon as I started laying out teh schematics, cable/connection drawing went tits up getting confused on which pins it would stick. Yesterday I tried ExpressPCB, (the link for the other one never came, talk about shitty). (feel free to suggest software that runs on other platforms, for everyone's reference, but personally am only interested in Win7-compatible programs) ![]() ![]() Please don't suggest commercial software, I am a hobbyist trying to learn, have no idea what I am doing, and have no money for such tings anyway. I only managed to make a rat's nest of a breadboard, but that didn't translate to a PCB by the autoroute at all, and when I tried to do it by hand is when it all failed.Īnyway I found a few options by googling like "ExpressPCB" and "Bay Area Circuits PCB Creator" which asks you for your email to send you the download link (annoying) and that link never arrived (quadruple annoying), but I'd like to hear from the hardware makers here. I spent my whole day today creating my own custom ICs and then it was reaaaaally messy to get it working properly (things don't snap into place properly, objects snap out of grids, etc). ![]() I'm trying to make a PCB (not that complicated but not that simple, lots of connections) and I tried Fritzing, but it was absolutely annoying to use. What is, according to you, the best PCB design software available for free? ![]() ![]() ![]() We do not host or distribute any applications. ![]() LEGAL DISCLAIMER: IPTV WIRE does not own or operate any IPTV service or streaming application. This is a popular alternative to traditional cable packages. There are thousands of IPTV apps and services and Mobdro APK is one of the best available. Mobdro can be installed on any Android-powered device including the Amazon Firestick, Fire TV, Fire TV Cube, NVIDIA Shield, and more.įor these reasons and more, you can find this app within our list of Best Free IPTV Apps.įor those unfamiliar with IPTV services, IPTV stands for “Internet protocol television.” In other words – live television through the Internet. These channel categories include news, sports, shows, movies, music, gaming, and much more! This is similar to other popular IPTV applications like Live Net TV or TVTap Pro that are free to use. Mobdro APK is a free IPTV app that provides hundreds of live channels mostly in SD quality. This guide will show how to install Mobdro APK on Firestick/Fire TV and review channels, favorites, and much more. Please refer to our news article below for more information and the best alternatives. IMPORTANT NOTE: Mobdro is currently offline and not working. ![]() ![]() ![]() A voice skin is language-specific and can either support Text-to-Speech or voice audio files. ![]() ![]() The scripts are used to generate voice instructions for navigation. VoiceSkin class encapsulates voice-generation scripts. You can use this class to display information about the voice skin before launching a download.Ī list of VoicePackage can be accessed by using VoiceCatalog.getCatalogList() method. Each voice package shares a common ID value with a downloadable voice skin. VoicePackage class represents an entry within the voice catalog. Note: A set of sample voice skins is packaged with SDK for Android in /files/voices-download VoicePackage Class ![]() ![]() This means it will be a little tougher to remove, too.I'm using Cura Version 4.10.0, and while the Preferences>General>Force layer view compatibility mode (restart requried), does change the preview of gray only to color, it does elimate the animated play. Lines is similar to zig-zag but has a bit more strength. It's easy to remove and prints very quickly. death notices weymouth Cura lets you choose from a variety of support patterns each of which is suited for a specific use case: Zig-zag is the standard support pattern and it is the default on most slicers. ![]() ![]() Cura Custom Support Plugin V2.5.2 New option with Freeform SupportCylindric Custom Support on . Install the “Cylindrical Custom Support” plugin and accept the License Agreement. Search “Custom Supports” under the “Plugins” tab. Click on the “Marketplace” in Cura’s top-right corner. The only changes we introduced compared to UltiMaker Cura 5.2.1 are those which are needed for the new supports.find your best offer here InterMountain CANADIAN NATIONAL 4-Bay Cylindrical Hopper #377571 NIB RTR 24/7 Customer Service High Quality Low Cost, C $91 Find many great new & used options and get the best deals for InterMountain CANADIAN NATIONAL 4-Bay Cylindrical Hopper #377571 NIB RTR at the best online prices at Free shipping for. Brought to you by our special community contributor We generated a special version of Cura 5.2 called 5.3.0 Alpha + Xmas. croydon council planning Then we would like to invite you to try this special release of UltiMaker Cura. ![]() ![]() This round neck pillow can bring comfortable support to any body part, whether it is neck pain, snoring, lumbar pain, leg numbness, or foot numbness, it can relieve the discomfort of the body and enjoy a good sleeping Length-17.7 inches,diameter-4.7 inches.Cura Custom Support Plugin V2.5.2 New option with Freeform SupportCylindric Custom Support on Github releas. ![]() ![]() ![]() ![]() Adobe, on the other hand, has discontinued its Flash Player software. This article discusses the best alternative to flash player in 2022!Īdobe Flash Player has been a great help to run internet applications, multimedia files, websites, and flash games. In 2020, Adobe will release an update that will remove support for Flash from mobile devices and browsers, which means that you won’t be able to view content created with the software on these platforms without an alternative. Many people are wondering about this alternative because of the impending death of Adobe Flash Player as we know it. The alternative to flash player in 2022 is a hot topic. ![]() ![]() ![]() There’s no shortage of mind-mapping software out there. What exactly should you look out for if you’re in the market for mind-map software? What Should You Look For in Mind Map Software? The best mind-mapping software would be tools that closely replicate the feeling of mind-mapping with pen and paper. Technological advancements in the 21st century have eventually led us to a point where we can use mind map software to create mind maps digitally.Īrguably, nothing beats the feeling and customizability that a hand-drawn mind map gives you. Traditionally, mind maps would be drawn by hand using pen and paper. By using them, you will be able to visualize your ideas and organize your information on a mind map. Today, there are plenty of mind mapping software that can help you to create digital mind maps. Mind mapping is a way of thinking that helps you to organize your information and ideas visually. Frequently Asked Questions About Mind Mapping Software for Windows and Mac.The Best Mind Mapping Apps and Software for Mac.The Best Mind Mapping Apps and Software for Microsoft Windows. ![]() ![]() What Should You Look For in Mind Map Software?. ![]() ![]() There’s no free plan available, but you can get a 3-months free trial when you sign up, so you have plenty of time to get used to the environment. Apple has also curated 90 million+ songs and 30,000 playlists for its users. However, our top contender for the all-around best music streaming platform is Apple Music – here’s why:Īpple Music is available in 160+ countries worldwide, with an excellent audio quality that supports up to high-resolution lossless audio at 24-bit/192 kHz. Most popular streaming services cost about $9.99/mo., so the choice is highly dependent on your personal taste. After canceling Spotify Premium, what music service should I use? If you miss the Spotify Premium features after unsubscribing, you may renew your subscription by following the same instructions as if you were signing up for the first time. Requesting Spotify Account deletion (From: Youtube/mrhackio)
![]() ![]() Known-flags Authority BadExit Exit Fast Guard HSDir Running Stable StaleDesc Sybil V2Dir Valid FallbackDir Unmeasured DescriptorMismatch Known-flags Authority Exit Fast Guard HSDir Running Stable StaleDesc Sybil V2Dir Valid ReachableIPv6 NoIPv6Consensus FallbackDir Unmeasured DescriptorMismatch Known-flags Authority Exit Fast Guard HSDir Running Stable StaleDesc Sybil V2Dir Valid FallbackDir Unmeasured DescriptorMismatch Known-flags Authority BadExit Exit Fast Guard HSDir Running Stable StaleDesc Sybil V2Dir Valid ReachableIPv6 NoIPv6Consensus FallbackDir Unmeasured DescriptorMismatch Known-flags Authority BadExit Exit Fast Guard HSDir Running Stable StaleDesc V2Dir Valid FallbackDir Unmeasured DescriptorMismatch Missing Signature! Valid-after time of auth's displayed consensus: 14:00:00 Note that it takes up to 15 minutes to learn about new consensus and votes and process them.Ĭonsensus ( microdesc) vote descriptors bandwidth file ![]() ![]() The detailed page which includes the (large) relay info table is also available.Ĭonsensus was published 15:00:00 UTC. This page shows statistics about the current consensus and votes to facilitate debugging of the directory consensus process. ![]() |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |